The hematologist reviewed Steven's case and recommended that he be treated with recombinant factor VIII. Steven's doctor explained that in the past, the hemophilia population was largely affected by blood-borne viruses, especially the hepatitis viruses and HIV. Although more expensive, this genetically engineered replacement product virtually eliminates the risk of blood-borne viruses.
Also see Workbook 8-21, 8-22
- 21. Why were males with hemophilia at such great risk for acquiring AIDS and other blood-borne viruses in the 1980's?
- 22. How have researchers helped to alleviate the problem of viral contamination?
- 23. How is recombinant DNA made?
- 24. What is gene therapy? Why is this looked at as a possible cure for hemophilia?
- 25. How does gene therapy work?
- 26. What is the current status of gene therapy research?
The hematologist recommended that Steven's parents make an appointment with a genetic counselor. The counselor could help them piece together the family history, and identify other siblings whose children may be at risk.
Also review the video: Just for fun: 18 Things You Should Know About Genetics
- 27. What is a gene?
- 28. What is DNA?
- 29. What is a chromosome?
- 30. What is a genome?
- 30. What is a gene varient? Differentiate between inherited and non-inherited variants.
Using the Workbook and the information under "Inheriting Genetic Conditions" be able to draw a punnett square for the following inheritance patterns: atosomal dominant, autosomal recessive, x-linked recessive.
Review principles of genetic testing:
- 31. What is genetic testing?
- 32. Why is genetic testing done?
- 33. What might be determined by a positive genetic testing result?
View X Linked Recessive video and review the link. Then answer the following questions:
- 34. How do boys inherit a gene varient for Hemophilia?